If you're looking to discover somewhere new, look no further than Mytilene. Whether you're planning to stay for a night or for the week, the area around Mytilene has accommodation options to fit every need. Search for hotels in Mytilene with Hotels.com by checking our online map. Our map displays the areas and neighbourhoods around all Mytilene hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Mytilene hotel deals are here with our lowest price guarantee.
Hotels in Mytilene
Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices
Check prices for these dates
Where to stay in Mytilene?

ISSA Lesvos
ISSA Lesvos
10.0 out of 10, Exceptional, (2)
The price is €113
includes taxes & fees
1 Jun - 2 Jun
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top landmarks in Mytilene
Port of Mytilene
Explore the waterfront in Mytilene with a trip to Port of Mytilene. While you're in the area, stroll along the seaside.
Learn more about Mytilene
Notable for its seaside, Mytilene features attractions such as Port of Mytilene and Mytilini Castle.

Frequently asked questions
Find out more about Mytilene
Find out more about Mytilene
Keep exploring
Keep exploring
- Landmarks
- Star Rating
- Accommodation Types
- Facilities
- Hotels close to nearby airports
- Nearby cities
- Top Cities in Greece
- More Hotels
- Most popular destinations
- Hotels near Port of Mytilene
- Hotels near Bus Station
- Hotels near Mytilini Castle
- Hotels near Thermi Beach
- Hotels near Thermes Gera Hot Springs
- Hotels near University of the Aegean
- Hotels near Roman Aqueduct at Moria
- Hotels near St Hermogenes Charamida Lesvos
- Hotels near Museum of the Memorial of the Refugees of 1922
- Hotels near Teriade Museum
- Hotels near Charamida Beach
- Hotels near Archaeological Site of Thermi
- Hotels near Ágios Ermogénis
- Hotels near Plaz Tsamákia
- Hotels near Church of Taxiarches
- Hotels near Temple of Messon
- Hotels near Church of Agios Therapon
- Hotels near Theophilos Museum
- Hotels near Nisélia
- Hotels near Theriade Library and Museum of Modern Art
- Athens Hotels
- Santorini Hotels
- Rhodes Hotels
- Corfu Hotels
- Mykonos Hotels
- Chania Hotels
- Hersonissos Hotels
- Zakynthos Hotels
- Naxos Hotels
- Paros Hotels
- Rethymno Hotels
- Kos Hotels
- Kefalonia Hotels
- Milos Hotels
- Skiathos Hotels
- Thessaloniki Hotels
- Heraklion Hotels
- Agios Nikolaos Hotels
- Lefkada Hotels
- Oia Hotels
- Zaira Hotel
- Mikamas Villa
- Villa Nufaro
- Ariadnes Holiday Accommodation
- Aeolian Gaea Hotel
- Kalloni Bay
- Olive Green Studios and Apartments
- Pebble Beach Hotel
- Aeolis Apartments & Studios
- Pasiphae Hotel
- Frini Studios
- Psaros Melinta
- Kaloni village apartments
- Palaiologou Panorama Apartments
- Aegeon Hotel
- Malemi Organic Hotel
- Ouzo Panoramic Houses 1, with private pool
- Maria Plomari Apartments
- Country Village House
- Gera's Olive Grove
- Shine Studios
- Ouzo Stone House 2, with private pool
- Ouzo Traditional House with private pool
- Ouzo Panoramic Houses 2, with private pool
Most popular destinations
Hotels
Hotels with a Gym in SardiniaAPA Hotel WoodbridgeThe Hoxton ParisHotels in Stoke-on-TrentNo. 377 HouseHotels in MirafloresAuraPigale Beach ResortBarceló Malaga HotelDublin Citi HotelHôtel L de Lutèce - Notre-DameThe S Hotel Al BarshaHotels in Downtown San DiegoHotel Continental Wellness & SpaWave Street InnSo-fresh So-clean Beautiful 3-bed House n BelfastHotels in MontclairFamily Hotels in AlvorHotels in County South DublinHotels in ThornwoodRamada by Wyndham Murree Lower Topa ResortRedcastle Hotel, Golf & SpaHotels in AberdeenAlua Gran Camp de MarClover Spa and HotelFromHere Cork Street Self CateringFamily Hotels in Santa PonsaHotel Lord ByronHotel SKALKaani Palm Beach