Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Santa Cruz on Hotels.com. These Santa Cruz hotels consistently deliver on comfort, location and traveler experience. Last updated on .
Hotels in Santa Cruz
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Top 5 hotels in Santa Cruz at a glance
- Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel — 3.5-star hotel in Santa Cruz. Guest rating: 9.0/10 — Wonderful.
- Camino Real Hotel — 4.5-star hotel in Santa Cruz. Guest rating: 9.0/10 — Wonderful.
- Hampton by Hilton Santa Cruz/Equipetrol, Bolivia — 4.5-star hotel in Santa Cruz. Guest rating: 9.2/10 — Wonderful.
- Hotel LP Santa Cruz Centro — 3-star hotel in Santa Cruz. Guest rating: 8.0/10 — Very Good.
- TRYP by Wyndham Santa Cruz — 4-star hotel in Santa Cruz. Guest rating: 9.2/10 — Wonderful.
Where to stay in Santa Cruz?

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio HotelSanta Cruz
9.0 out of 10, Wonderful, (384 reviews)
$127 nightly
The price is $127
Jul 10 - Jul 11

Camino Real Hotel
Camino Real HotelSanta Cruz
9.0 out of 10, Wonderful, (428 reviews)
$162 nightly
The price is $162
Aug 1 - Aug 2

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia
Hampton by Hilton Santa Cruz/Equipetrol, BoliviaSanta Cruz
9.2 out of 10, Wonderful, (279 reviews)
$74 nightly
The price is $74
Jul 19 - Jul 20

Hotel LP Santa Cruz Centro
Hotel LP Santa Cruz CentroSanta Cruz
8.0 out of 10, Very Good, (285 reviews)
$54 nightly
The price is $54
Jul 3 - Jul 4

TRYP by Wyndham Santa Cruz
TRYP by Wyndham Santa CruzSanta Cruz
9.2 out of 10, Wonderful, (166 reviews)
$98 nightly
The price is $98
Jul 2 - Jul 3

Hotel LP Equipetrol
Hotel LP EquipetrolSanta Cruz
8.2 out of 10, Very Good, (209 reviews)
$44 nightly
The price is $44
Jul 10 - Jul 11

Marriott Santa Cruz de la Sierra Hotel
Marriott Santa Cruz de la Sierra HotelSanta Cruz
9.0 out of 10, Wonderful, (236 reviews)
$122 nightly
The price is $122
Jul 10 - Jul 11

Ibis Santa Cruz DE LA Sierra
Ibis Santa Cruz DE LA SierraSanta Cruz
9.4 out of 10, Exceptional, (124 reviews)
$53 nightly
The price is $53
Jul 16 - Jul 17

Cosmopolitano Hotel Boutique
Cosmopolitano Hotel BoutiqueSanta Cruz
9.2 out of 10, Wonderful, (133 reviews)
$95 nightly
The price is $95
Jul 5 - Jul 6

Hotel Cortez
Hotel CortezSanta Cruz
9.2 out of 10, Wonderful, (144 reviews)
$98 nightly
The price is $98
Jul 17 - Jul 18

Premium Suites Deluxe Aparthotel Equipetrol
Premium Suites Deluxe Aparthotel EquipetrolSanta Cruz
9.0 out of 10, Wonderful, (108 reviews)
$42 nightly
The price is $42
Jul 3 - Jul 4

HOTEL OSHO
HOTEL OSHOSanta Cruz
9.2 out of 10, Wonderful, (51 reviews)
$63 nightly
The price is $63
Jul 19 - Jul 20

Delfines Collection Hotel By Mercure
Delfines Collection Hotel By MercureSanta Cruz
9.0 out of 10, Wonderful, (95 reviews)
$48 nightly
The price is $48
Jul 17 - Jul 18

Alfonsina Hotel Boutique by Inboccaluppo
Alfonsina Hotel Boutique by InboccaluppoSanta Cruz
9.4 out of 10, Exceptional, (44 reviews)
$108 nightly
The price is $108
Jul 2 - Jul 3

Prince Hotel
Prince HotelSanta Cruz
8.8 out of 10, Excellent, (6 reviews)
$51 nightly
The price is $51
Jul 10 - Jul 11

Novotel Santa Cruz De La Sierra
Novotel Santa Cruz De La SierraSanta Cruz
9.0 out of 10, Wonderful, (118 reviews)
$109 nightly
The price is $109
Jul 5 - Jul 6

Apart Hotel Toborochi
Apart Hotel ToborochiSanta Cruz
8.8 out of 10, Excellent, (60 reviews)
$77 nightly
The price is $77
Jul 2 - Jul 3

Swissôtel Santa Cruz De La Sierra
Swissôtel Santa Cruz De La SierraSanta Cruz
9.2 out of 10, Wonderful, (87 reviews)
$101 nightly
The price is $101
Jul 16 - Jul 17

Yotau All Suites Hotel
Yotau All Suites HotelSanta Cruz
7.0 out of 10, Good, (76 reviews)
$113 nightly
The price is $113
Jul 2 - Jul 3
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Showing deals for:Jul 3 - Jul 5

9.2 out of 10, Wonderful, (87 reviews)
$126 nightly
The price is $252
Showing deals for:Jul 10 - Jul 12

9.2 out of 10, Wonderful, (87 reviews)
$113 nightly
The price is $226
Showing deals for:Jul 31 - Aug 1

9.2 out of 10, Wonderful, (87 reviews)
$101 nightly
The price is $101
Check out hotels with a pool in Santa Cruz

8.6 out of 10, Excellent, (8)
$64 nightly
The price is $64
Jul 3 - Jul 4
You may also like pet-friendly hotels in Santa Cruz
$47 nightly
The price is $47
Jul 9 - Jul 10
You can also stay at hotels with a spa in Santa Cruz

9.0 out of 10, Wonderful, (236)
$122 nightly
The price is $122
Jul 10 - Jul 11
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Santa Cruz
Top neighborhoods in Santa Cruz
Top landmarks in Santa Cruz
Learn more about Santa Cruz
Santa Cruz is applauded for its cultural attractions such as Ethno-folkloric Museum and Cine Center.

Check out reviews of Santa Cruz hotels guests love

TRYP by Wyndham Santa Cruz
10/10 Excellent
Frequently asked questions
Find out more about Santa Cruz
Keep exploring
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- Hotels near Catedral de Santa Cruz
- Hotels near Lomas de Arena Regional Park
- Hotels near Sacred Art Museum
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- Hotels near Museo Ruta del Che & Museo Arqueólogico
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