Hotels in Santa Cruz

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Where to stay in Santa Cruz?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Santa Cruz on Hotels.com. These Santa Cruz hotels consistently deliver on quality, location and traveller experience. Last updated on 1 November 2026.

A modern hotel room with a large bed, a bedside table with a lamp, a small bench, and a glass-enclosed bathroom.

1. Cosmopolitano Hotel Boutique

Centro Histórico

2 Nov - 3 Nov

A spacious living area with a high ceiling, wooden beams, a staircase, and a view of a balcony.

2. Lido Hotel

Centro Histórico

2 Nov - 3 Nov

A modern hotel lobby with a reception desk, seating area, and a large glass wall with a sign.

3. Ibis Santa Cruz DE LA Sierra

Equipetrol

20 Nov - 21 Nov

A modern hotel with a rooftop pool featuring illuminated blue and purple lights, lounge chairs, and a palm tree.

4. Marriott Santa Cruz de la Sierra Hotel

Santa Cruz

8 Nov - 9 Nov

A hotel with a large swimming pool, multiple balconies, and a central arched entrance.

5. Sun Hotel

Santa Cruz

2 Nov - 3 Nov

A modern bedroom with a bed, bedside table, and a desk with a laptop.

6. Hotel G

Santa Cruz

30 Nov - 1 Dec

A modern restaurant with a city view, featuring glass tables, white chairs, and a large window with curtains.

7. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Santa Cruz

7 Nov - 8 Nov

A poolside area with lounge chairs and a palm tree.

8. Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Equipetrol

9 Nov - 10 Nov

A hotel room with a large bed, bedside tables, a desk with a chair, a small refrigerator, and a TV mounted on the wall.

9. HOTEL OSHO

Santa Cruz

2 Nov - 3 Nov

A balcony with a table set for breakfast, including a plate of fruit, a glass of orange juice, and a cup. The view includes a cityscape with buildings and a clear sky.

10. Hotel Las Américas

Centro Histórico

5 Nov - 6 Nov

The exterior of the ECO HOTEL with illuminated signage and a wooden canopy.

11. Chairú Eco Hotel

Santa Cruz

10 Nov - 11 Nov

12. Apart Hotel Premium Suites Santa Cruz

Santa Cruz

2 Nov - 3 Nov

A rooftop pool with clear skies and a city view.

13. Hotel Pascana centro

Centro Histórico

2 Nov - 3 Nov

A rooftop pool with a water feature, surrounded by modern buildings and a clear sky.

14. Premium Suites Deluxe Aparthotel Equipetrol

Santa Cruz

2 Nov - 3 Nov

An outdoor dining area with tables and chairs, surrounded by plants and palm trees.

15. Terranova Suites

Santa Cruz

3 Nov - 4 Nov

A swimming pool with a decorative center, surrounded by a building with a blue roof and a mural.

16. Gran Hotel Santa Cruz

Centro Histórico

2 Nov - 3 Nov

A modern building with the sign "TRYP SANTA CRUZ" and a glass entrance with decorative lighting.

17. TRYP by Wyndham Santa Cruz

Equipetrol

2 Nov - 3 Nov

18. Hotel Maywa

Santa Cruz

2 Nov - 3 Nov

A buffet setup with various food items and beverages.

19. Hotel LP Equipetrol

Equipetrol

20 Nov - 21 Nov

A rooftop pool with a glass barrier reflecting the sunset and city skyline.

20. Delfines Collection Hotel By Mercure

Equipetrol

16 Nov - 17 Nov

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Cosmopolitano Hotel Boutique

Centro Histórico

for 2 nights, 1 room

€50 per night

Ibis Santa Cruz DE LA Sierra

Equipetrol

for 2 nights, 1 room

€37 per night

A building entrance with steps leading up to a glass door, a plaque reading "Coco Kl Primer B", and a sign for "Inmobili Calupo".

Alfonsina Hotel Boutique by Inboccaluppo

Equipetrol

€90 off

for 2 nights, 1 room

€112 per night

Apart Hotel Premium Suites Santa Cruz

Santa Cruz

€5 off

for 2 nights, 1 apartment

€24 per night

Cosmopolitano Hotel Boutique

Centro Histórico

for 1 room

Ibis Santa Cruz DE LA Sierra

Equipetrol

for 1 room

Alfonsina Hotel Boutique by Inboccaluppo

Equipetrol

for 1 room

Apart Hotel Premium Suites Santa Cruz

Santa Cruz

€3 off

for 1 apartment

Check out pet-friendly hotels in Santa Cruz

Ibis Santa Cruz DE LA Sierra

Equipetrol

20 Nov - 21 Nov

View all properties

Go beyond your typical stay in Santa Cruz

Pet friendly

Pool

Our prices for hotels in Santa Cruz are cheapest in January

Top neighbourhoods in Santa Cruz

Equipetrol

Santa Cruz's Equipetrol neighbourhood offers attractions, including Santa Cruz Zoo.

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Centro Histórico

Santa Cruz's Centro Histórico neighbourhood is home to attractions, such as Plaza 24 de Septiembre and La Recova Artisan Walk.

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Top landmarks in Santa Cruz

A historic building with arched windows and a clock. People are sitting and standing on the steps in front of the building.

Plaza 24 de Septiembre

8.8/10 (164 reviews)

If you're planning a bit of sightseeing, head to Plaza 24 de Septiembre – just one of the monuments in Centro Histórico.

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Learn more about Santa Cruz

Santa Cruz is applauded for its cultural attractions such as Ethno-folkloric Museum and Cine Center.

See all hotels in Santa Cruz

A historic cathedral with two prominent towers, surrounded by urban buildings and palm trees.

Check out reviews of Santa Cruz hotels guests love

TRYP by Wyndham Santa Cruz

10/10 Excellent

"Habitaciones y todas las instalaciones estaban limpias, personal muy amable y atento. Ubicado en equipetrol con todo cerca"

Hotel Cortez

10/10 Excellent

"El hotel es fantastico, el desayuno excelente, los servicios que brinda el hotel son un plus para el huésped. En general, el personal es atento y amable. Sin embargo, tuvimos problemas en el check in, la señorita que nos recibió indicó que no teníamos reservación. Se le indicó que la reservación se había hecho por Expedia y ella insistió en que no teníamos alguna. Cuando llamé a Expedia, nos dijo que, aunque el hotel estaba lleno, nos darían una habitación. Esta señorita parece no ser tan amable, lo cual es la excepción, pues el personal es atento y presto a ayudar al huésped."

Frequently asked questions

Can I book a refundable accommodation option in Santa Cruz?

If you want the flexibility to change your plans to Santa Cruz, most hotels offer refundable* rates that you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where can I stay in Santa Cruz if I want a holiday rental instead of a hotel?

If you want to find a good alternative to a hotel, review our selection of 23 holiday homes. In addition, you can choose from 198 apartments.

What will the weather in Santa Cruz be like during my visit?

Santa Cruz is a great place to visit to enjoy the sunshine at any time of year, with an average temp of 21°C.

Why should I book my Santa Cruz hotel with Hotels.com?

There are lots of reasons to book your Santa Cruz trip with us: our free cancellations on selected hotels* gives you flexibility, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.

Find out more about Santa Cruz

Awakening the Senses: Discover the Floral Symphony and Sacred Splendor of Santa Cruz

Discover Santa Cruz, Bolivia, a vibrant city where modernity meets rich culture. Stroll through lush parks adorned with colourful flowers, and marvel at the stunning architecture of the iconic Cathedral Metropolitana. Experience the lively atmosphere of the Mercado Los Pozos, where local flavours abound. Just outside the city, the expansive Parque Nacional Amboró beckons with its breathtaking landscapes and diverse wildlife. Whether you're seeking cultural immersion, culinary delights, or natural wonders, Santa Cruz offers an enchanting blend of experiences that will captivate every traveller.

Discover great hotels in Santa Cruz

Santa Cruz, Bolivia, offers a diverse range of accommodation options, from boutique hotels to modern hostels. Visitors can enjoy comfortable stays with local flair, convenient access to attractions, and a vibrant atmosphere. Whether you seek luxury or budget-friendly choices, Santa Cruz has plenty to accommodate your needs. Here are some of the most popular hotels with our travelers in Santa Cruz:

Los Cedros Resort & Convention CenterOpens in a new window: This charming 3.5-star hotel provides a comfortable retreat with a range of delightful amenities. Guests can indulge in a complimentary buffet breakfast, enjoy lunch and dinner at the onsite restaurant, or unwind at the bar and lounge area. The property features fitness facilities for those looking to maintain their active lifestyle. The inviting atmosphere and quality dining options create a relaxing environment, making it a popular choice for leisure travellers seeking a pleasant stay in Santa Cruz.
Novotel Santa Cruz De La SierraOpens in a new window: Elevating the concept of luxury, Novotel Santa Cruz De La Sierra is a stunning 5.0-star hotel designed for travellers in pursuit of an exceptional family vacation experience. This property boasts a variety of enriching amenities for children, including a shared playground and an engaging games room. The sophisticated architectural design and upscale dining options make this hotel a highly sought-after destination. Families appreciate the thoughtfully curated experiences that enhance their stay, ensuring a memorable and enjoyable getaway in Santa Cruz.
Marriott Santa Cruz de la Sierra HotelOpens in a new window: Marriott Santa Cruz de la Sierra Hotel is a sophisticated 5.0-star hotel that caters primarily to business travellers. With multiple meeting rooms and comprehensive business centre facilities, it provides an ideal environment for seamless corporate engagements. The property also offers child-friendly amenities, making it suitable for those travelling with family while maintaining a focus on professional needs. Its elegant design and well-appointed spaces create a refined atmosphere, ensuring a productive yet comfortable experience for those on business trips.

Top locations to stay in Santa Cruz

When visiting Santa Cruz, Santa Cruz, Bolivia, consider staying in La Cruceña, Las Barreras, and El Torno. La Cruceña offers vibrant local culture, while Las Barreras is known for its scenic views and outdoor activities. El Torno boasts beautiful natural landscapes. For first-time visitors, La Cruceña is the best choice, providing easy access to local attractions.

La CruceñaOpens in a new window: La Cruceña is a vibrant area in Santa Cruz, perfect for those looking to immerse themselves in local culture and cuisine. The lively atmosphere invites you to explore its bustling markets and shops, where you can find unique handicrafts and local delicacies. Don't miss the beautiful parks and squares that offer a serene escape right in the heart of the city. With a variety of cultural attractions nearby, including galleries and artisan fairs, La Cruceña is an excellent base for experiencing the rich heritage of Bolivia.
Las BarrerasOpens in a new window: Las Barreras is known for its stunning natural surroundings and is ideal for travellers seeking a peaceful retreat close to nature. The area boasts picturesque landscapes, making it a great spot for leisurely walks and outdoor picnics. You can enjoy activities like bird watching or simply relax while soaking in the tranquil atmosphere. Las Barreras also provides easy access to local artisan markets where you can purchase beautiful handmade crafts, adding a unique touch to your travel experience.
El TornoOpens in a new window: El Torno is a charming destination that offers a true taste of Bolivian rural life. The area is surrounded by lush greenery and natural parks, perfect for adventurous spirits wanting to explore the great outdoors. While El Torno may be smaller, its warm community vibe and local festivals add to its appeal. The region is known for its agricultural activities, so you can enjoy fresh produce and engage with local farmers, making it a delightful spot for those looking to connect with the land and its people.

Things to do in Santa Cruz

Santa Cruz beckons with its stunning coastline, lush forests, and picturesque mountains. Here, you can indulge in leisurely beach days, hike scenic trails, or enjoy vibrant local markets. With opportunities for birdwatching and spirited soccer matches, it’s a delightful destination for nature lovers and active souls alike.

Palestina ChurchOpens in a new window – Step inside this charming church and admire its serene interior, adorned with beautiful floral arrangements. The architecture invites quiet reflection and offers a peaceful escape from the bustling city.
Municipal LibraryOpens in a new window – Discover a world of knowledge at the Municipal Library. Wander through its extensive collection of books and resources, perfect for a leisurely afternoon. The library’s tranquil atmosphere makes it an ideal spot to read or study.
Ethno-folkloric MuseumOpens in a new window – Dive into the rich cultural heritage of Bolivia at the Ethno-folkloric Museum. Explore fascinating exhibits showcasing traditional crafts, costumes, and folk art that tell stories of the region’s diverse communities.
Arenal ParkOpens in a new window – Enjoy a breath of fresh air at Arenal Park, where lush greenery and vibrant flowers create a perfect backdrop for a picnic or a leisurely stroll. The park is great for unwinding and soaking up the sunshine.
Plaza 24 de SeptiembreOpens in a new window – Visit the lively Plaza 24 de Septiembre, the heart of Santa Cruz. This vibrant square is perfect for people-watching, enjoying local street food, or simply relaxing amidst the colourful surroundings and sculptures.

4 tips for savvy savings when booking a hotel in Santa Cruz

Book for the cheapest times: The most affordable time to visit Santa Cruz is during June, August, and November, when hotel prices tend to be lower. For a budget-friendly experience, a stay of at least 3 to 4 days is recommended to thoroughly explore the city's key landmarks and cultural attractions. During your visit, you can enjoy excursions to historical sites, indulge in shopping at local boutiques, relax at charming cafes, admire beautiful flowers, visit the zoo, and partake in birdwatching. Additionally, the vibrant local soccer scene and various business establishments, including breweries, offer great value for money in terms of cultural immersion.
Look for last-minute deals on Hotels.com: To uncover last-minute deals to Santa Cruz, begin by exploring the DealsOpens in a new window or Last-Minute Deals sections on Hotels.com, where you may discover discounted rates on nearby hotels as your travel date approaches. Additionally, consider enabling email alerts or push notifications to stay informed about flash sales and special offers, ensuring you could find opportunities to save. The Smart Shopping tool available via the app allows you to compare hotel prices and amenities, helping you make informed decisions. By staying updated on price changes and availability, you're more likely to seize a last-minute getaway.
Be flexible with dates: Prices can fluctuate depending on factors such as the hotel's location, star rating, and the time of year, so being flexible with your travel dates might help you save on your stay in a Santa Cruz hotel. For those seeking something distinctive, boutique hotels can provide a more personalised experience and potentially better value. When you book through Hotels.com, we’ll inform you whether the price for your chosen dates is above or below the average. If the price is on the higher side, we’ll suggest alternative dates that may be more affordable, increasing the likelihood of finding a better deal.
Consider your location: Hotels situated near the city centre generally tend to be more expensive, but with Santa Cruz's superb public transport links, you may discover a more affordable independent hotel a bit further out that remains well connected. For those keen to explore alternative, less crowded neighbourhoods or even lesser-known nearby towns, there is often excellent value for money to be found. Opting for these alternative destinations could provide a more authentic and budget-friendly experience.

Best time to go to Santa Cruz

Santa Cruz experiences its lowest average temperature in June, at 67.8°F (19.9°C), while October are the hottest months, with an average temperature of 79.5°F (26.4°C). January is usually the wettest month. January, July, and September are the peak travel months in Santa Cruz, attracting a higher number of tourists. During this peak period, the weather is sunny to mostly sunny, accompanied by no to light rainfall. On the other hand, May, October, and December tend to be quieter times to visit, marked by light rainfall and mostly sunny conditions.

Hotels in Santa Cruz

Free cancellation options if plans change

Earn rewards on every night you stay

Save more with Member Prices

Check prices for these dates

Where to stay in Santa Cruz?

1. Cosmopolitano Hotel Boutique

2. Lido Hotel

3. Ibis Santa Cruz DE LA Sierra

4. Marriott Santa Cruz de la Sierra Hotel

5. Sun Hotel

6. Hotel G

7. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

8. Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

9. HOTEL OSHO

10. Hotel Las Américas

11. Chairú Eco Hotel

12. Apart Hotel Premium Suites Santa Cruz

13. Hotel Pascana centro

14. Premium Suites Deluxe Aparthotel Equipetrol

15. Terranova Suites

16. Gran Hotel Santa Cruz

17. TRYP by Wyndham Santa Cruz

18. Hotel Maywa

19. Hotel LP Equipetrol

20. Delfines Collection Hotel By Mercure

Get last-minute hotel deals in Santa Cruz and save more

Cosmopolitano Hotel Boutique

Cosmopolitano Hotel Boutique

Check out pet-friendly hotels in Santa Cruz

Ibis Santa Cruz DE LA Sierra

You may also like hotels with pools in Santa Cruz

Cosmopolitano Hotel Boutique

Go beyond your typical stay in Santa Cruz

When is the best time to visit Santa Cruz?

Price trends for hotels in Santa Cruz

Typical weather for Santa Cruz

Top neighbourhoods in Santa Cruz

Equipetrol

Centro Histórico

Hamacas

Zona Sur (South Zone)

Urubó

Top landmarks in Santa Cruz

Plaza 24 de Septiembre

Learn more about Santa Cruz

Check out reviews of Santa Cruz hotels guests love

TRYP by Wyndham Santa Cruz

Frequently asked questions

Find out more about Santa Cruz

Awakening the Senses: Discover the Floral Symphony and Sacred Splendor of Santa Cruz

Discover great hotels in Santa Cruz

Top locations to stay in Santa Cruz

Things to do in Santa Cruz

4 tips for savvy savings when booking a hotel in Santa Cruz

Best time to go to Santa Cruz

Keep exploring