Hotels in Santee

Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices

Check prices for these dates

Tonight
24 May - 25 May
Tomorrow
25 May - 26 May
Next weekend
30 May - 1 Jun
In two weeks
6 Jun - 8 Jun

Where to stay in Santee?

Lewis and Clark Resort
32-inch LCD TV with digital channels, TV

Lewis and Clark Resort

2.5 star property
8.8 out of 10, Excellent, (210)
The price is €118
includes taxes & fees
26 May - 27 May
Lewis and Clark Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Santee

Niobrara showing a river or creek and boating as well as a small group of people

Niobrara State Park

You can take time to visit Niobrara State Park during your travels to Niobrara. While you're in the area, wander around the parks.

See properties in Niobrara State Park
Niobrara State Park

Learn more about Santee

The region around Santee is home to attractions such as Lewis and Clark Lake and Niobrara State Park.

See all hotels in Santee

Frequently asked questions

Can I book a refundable accommodation option in Santee?
If you want the flexibility to change your plans to Santee, most hotels offer refundable* rates that you can book. You can find these properties by searching our site and using the “fully refundable” filter to narrow down the results.
What will the weather in Santee be like during my visit?
The warmest months in Santee are usually July and August, with an average temperature of 22°C. January and February are the chilliest months, when the average temperature is -3°C. The rainiest months are June and May.
Why should I book my Santee hotel with Hotels.com?
There are lots of reasons to book your Santee trip with us: our free cancellations on selected hotels* gives you flexibility, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.