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Hotels in Cape Girardeau

October 2026
November 2026

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Next weekend
2 Oct - 4 Oct
In two weeks
9 Oct - 11 Oct

Where to stay in Cape Girardeau?

Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Cape Girardeau on Hotels.com. These Cape Girardeau hotels consistently deliver on quality, location and traveller experience. Last updated on 26 September 2026.
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

1. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
€99
includes taxes & fees
4 Oct - 5 Oct
Drury Plaza Hotel Cape Girardeau Conference Center
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.
A hotel room with two beds, a desk, a chair, and a view of the city.

2. The Riverview

The Riverview
Cape Girardeau
€113
includes taxes & fees
30 Sept - 1 Oct
The Riverview
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

3. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
€89
includes taxes & fees
9 Oct - 10 Oct
Drury Inn & Suites Cape Girardeau
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

4. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
€71
includes taxes & fees
4 Oct - 5 Oct
Pear Tree Inn Cape Girardeau West
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

5. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
€101
includes taxes & fees
4 Oct - 5 Oct
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A spacious lobby with marble flooring, elegant seating, and a grand staircase.
A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.
A spacious living room with a sofa set, a coffee table, and a dining area.
A lobby with seating areas, a reception desk, and a bar.

6. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
Cape Girardeau
€124
includes taxes & fees
8 Oct - 9 Oct
Courtyard by Marriott Cape Girardeau Downtown
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.
A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

7. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
€100
includes taxes & fees
4 Oct - 5 Oct
Fairfield Inn & Suites by Marriott Cape Girardeau
A modern retail area with a display of local items and snacks.
A hotel room with two beds, a desk, a chair, a TV, and a window with a view.
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.

8. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
€89
includes taxes & fees
4 Oct - 5 Oct
Tru By Hilton Cape Girardeau
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
An outdoor patio with stone walls, wicker furniture, and large windows.
A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.

9. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
€105
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn Cape Girardeau I 55 East
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel room with a bed, a TV, a desk, and a chair.
A hotel patio with a gazebo, outdoor seating, and a view of the road.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

10. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
€89
includes taxes & fees
11 Oct - 12 Oct
Candlewood Suites Cape Girardeau by IHG
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.
A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.

11. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
Cape Girardeau
€59
includes taxes & fees
11 Oct - 12 Oct
Quality Inn Cape Girardeau North
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.
A bathroom with a marble wall and a white bathtub.
A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.
A hotel room with a kitchenette, a bed, a dining table with chairs, a TV mounted on the wall, and a dresser.

12. Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
Cape Girardeau
€77
includes taxes & fees
27 Sept - 28 Sept
Town House Inn Cape Giradreau
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
An outdoor patio with tables and chairs, a stone wall, and large windows.
A breakfast bar with a coffee machine, waffle maker, toaster, and various food items.
A hotel room with two beds, a nightstand, a lamp, and a chair.

13. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
€80
includes taxes & fees
27 Sept - 28 Sept
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A restaurant with a brick wall, a flat-screen TV, and a bar area.
A Drury Inn & Suites building with a traditional architectural style, featuring a covered entrance and multiple windows.
A hotel room with two beds, a brick wall, and a wooden headboard.

14. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
€79
includes taxes & fees
12 Oct - 13 Oct
Drury Inn & Suites Jackson MO
A spacious lobby with large windows, comfortable seating, and a modern ceiling design.
A gym with treadmills, an elliptical, a bench, and a rack of dumbbells.
A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.
A room with large windows, two red upholstered chairs, a small table, and a potted plant.

15. Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
Jackson
€72
includes taxes & fees
25 Oct - 26 Oct
Comfort Suites Jackson-Cape Girardeau
A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.
A hotel room with two beds, a wooden dresser, a bathroom with a shower, and a kitchen area.
A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.

16. Town House Inn

Town House Inn
Jackson
€68
includes taxes & fees
27 Sept - 28 Sept
Town House Inn
A living room with a blue wall, a fireplace, a sofa, and a chair.
A sign for EC REED'S MERCANTILE & HOTEL with a geometric design.
A brick building with a sign reading "Mercantile & Hotel".
A hotel room with two beds, a vanity with a mirror, a chair, and a dresser.

17. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
Marble Hill
€100
includes taxes & fees
4 Oct - 5 Oct
EC Reed's Mercantile and Hotel
A rustic lodge with a steeply pitched roof, a central entrance with a door, and a porch with multiple lights.
A stone building with a patio area, string lights, and outdoor seating.
A cozy living room with a brown leather sofa, a wooden coffee table, and a window with a view of trees.
A cozy log cabin interior with a wooden staircase, a cushioned sofa, a small table, and a lamp.

18. Makanda Inn

Makanda Inn
Makanda
€262
includes taxes & fees
27 Sept - 28 Sept
Makanda Inn
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Check out pet-friendly hotels in Cape Girardeau

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
€99
includes taxes & fees
4 Oct - 5 Oct
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.

Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
€71
includes taxes & fees
4 Oct - 5 Oct
Pear Tree Inn Cape Girardeau West
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
€89
includes taxes & fees
9 Oct - 10 Oct
Drury Inn & Suites Cape Girardeau
A modern retail area with a display of local items and snacks.
A hotel room with two beds, a desk, a chair, a TV, and a window with a view.
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
€89
includes taxes & fees
4 Oct - 5 Oct
Tru By Hilton Cape Girardeau
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
An outdoor patio with stone walls, wicker furniture, and large windows.
A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
€105
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn Cape Girardeau I 55 East
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel room with a bed, a TV, a desk, and a chair.
A hotel patio with a gazebo, outdoor seating, and a view of the road.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
€89
includes taxes & fees
11 Oct - 12 Oct
Candlewood Suites Cape Girardeau by IHG
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.
A bathroom with a marble wall and a white bathtub.
A motel with multiple floors, a parking lot, and a staircase leading to the upper floors.
A hotel room with a kitchenette, a bed, a dining table with chairs, a TV mounted on the wall, and a dresser.

Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
Cape Girardeau
€77
includes taxes & fees
27 Sept - 28 Sept
Town House Inn Cape Giradreau
View all properties

You can also stay at hotels with a pool in Cape Girardeau

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A Drury Plaza Hotel with a modern design, featuring a prominent entrance, multiple floors, and a clear sky.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
€99
includes taxes & fees
4 Oct - 5 Oct
Drury Plaza Hotel Cape Girardeau Conference Center
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
€89
includes taxes & fees
9 Oct - 10 Oct
Drury Inn & Suites Cape Girardeau
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.
A hotel room with a bed, desk, chair, TV, and a small kitchenette area.

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
€101
includes taxes & fees
4 Oct - 5 Oct
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A modern retail area with a display of local items and snacks.
A hotel room with two beds, a desk, a chair, a TV, and a window with a view.
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.

Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
€89
includes taxes & fees
4 Oct - 5 Oct
Tru By Hilton Cape Girardeau
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.
A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.

Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
€100
includes taxes & fees
4 Oct - 5 Oct
Fairfield Inn & Suites by Marriott Cape Girardeau
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
An outdoor patio with stone walls, wicker furniture, and large windows.
A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.

Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
€105
includes taxes & fees
4 Oct - 5 Oct
Hampton Inn Cape Girardeau I 55 East
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel room with a bed, a TV, a desk, and a chair.
A hotel patio with a gazebo, outdoor seating, and a view of the road.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.

Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
€89
includes taxes & fees
11 Oct - 12 Oct
Candlewood Suites Cape Girardeau by IHG
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A reception desk with a green wall, a wooden door, and a sign that reads 'QUALITY INN.'
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.
A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
Cape Girardeau
€59
includes taxes & fees
11 Oct - 12 Oct
Quality Inn Cape Girardeau North
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Go beyond your typical stay in Cape Girardeau

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Pet friendly
Pet friendly
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Pool
Pool
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Hot tub
Hot tub
spa image
Spa
Spa
Family-friendly image
Family friendly
Family friendly
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Cottage
Cottage
Our prices for hotels in Cape Girardeau are cheapest in December

Price trends for hotels in Cape Girardeau

Pricing is based on two traveller single night rates
View properties in September

September

High 28°C / low 17°C. Sunny most days.
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Monthly weather averages (˚C)

Top landmarks in Cape Girardeau

A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)
If you'd like to get a taste of Cape Girardeau student life, check out Southeast Missouri State University, located 0.9 mi (1.4 km) from central Cape Girardeau.
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A cable-stayed bridge over a river with a rocky shoreline in the foreground.

Riverfront Bridge Park

8.8/10 (129 reviews)
Riverfront Bridge Park is worth a visit, located 0.7 mi (1.1 km) from central Cape Girardeau.
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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)
Century Casino & Hotel Cape Girardeau is 0.5 mi (0.8 km) from central Cape Girardeau, why not stop by during your stay?
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Hunter Valley Winery

7.4/10 (48 reviews)
Travellers might want a tour of Hunter Valley Winery, just one of the places to visit, located 9.3 mi (14.9 km) from central Cape Girardeau.
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Riverfront Park

8.0/10 (2 reviews)
Riverfront Park is worth a visit when in central Cape Girardeau.
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Show Me Center

8.6/10 (40 reviews)
You can catch an event at Show Me Center, located 1.1 mi (1.8 km) from central Cape Girardeau.
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Cape Splash Family Aquatic Center

8.6/10 (21 reviews)
Why not give yourself a treat with a trip to Cape Splash Family Aquatic Center, one of the family attractions located 3.1 mi (5.1 km) from central Cape Girardeau? If you have fun at Cape Splash Family Aquatic Center, you'll love Cape Girardeau Conservation Nature Center, located nearby.
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Cape Rock Park

8.6/10 (36 reviews)
Cape Rock Park is worth a visit, located 1.9 mi (3.1 km) from central Cape Girardeau.
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Learn more about Cape Girardeau

Hugging the Mississippi River, this college town reveals its history through vibrant floodwall murals that transform concrete into an outdoor gallery. Southeast Missouri State University brings youthful energy to streets lined with locally-owned shops and cafes. The River Campus hosts performances in a former seminary with river views. Explore the Cape Girardeau Conservation Nature Centre or paddle the Mississippi. Trail of Tears State Park offers hiking paths with panoramic vistas that explain why settlers chose this dramatic spot. The Cape Riverfront Market buzzes with farmers and artisans, while the historic city centre invites exploration with red-brick buildings housing quirky boutiques and restaurants serving hearty Midwestern fare with surprising sophistication.

See all hotels in Cape Girardeau
A nighttime view of a bridge with its cables illuminated against a starry sky.

Frequently Asked Questions

Can I book a refundable accommodation option in Cape Girardeau?

If you want the flexibility to change your plans to Cape Girardeau, most hotels offer refundable* rates that you can book. You can find these properties by searching our site and using the "fully refundable" filter to narrow down the results.

Where can I stay in Cape Girardeau if I want a holiday rental instead of a hotel?

If you want to find a good alternative to a hotel, review our selection of 30 holiday homes. In addition, you can choose from 20 apartments.

What will the weather in Cape Girardeau be like during my visit?

July and August are typically the warmest months in Cape Girardeau, when the average temperature is 25°C. January and February are the coldest months, when the average temperature is 5°C. April and March are the months with the most rain.

Why should I book my Cape Girardeau hotel with Hotels.com?

There are lots of reasons to book your Cape Girardeau trip with us: our free cancellations on selected hotels* gives you flexibility, our Price Guarantee ensures that you always get the lowest price, and you can earn rewards on every booking.

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