Properties are selected based on real traveller reviews and popularity among guests who’ve booked a night in Cape Girardeau on Hotels.com. These Cape Girardeau hotels consistently deliver on quality, location and traveller experience. Last updated on .
Hotels in Cape Girardeau
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4 Sept - 5 SeptTomorrow
5 Sept - 6 SeptThis weekend
4 Sept - 6 SeptNext weekend
11 Sept - 13 SeptWhere to stay in Cape Girardeau?
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
€99
includes taxes & fees
24 Sept - 25 Sept
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
€97
includes taxes & fees
13 Sept - 14 Sept
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau WestCape Girardeau
€70
includes taxes & fees
27 Sept - 28 Sept
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Cape GirardeauCape Girardeau
€87
includes taxes & fees
13 Sept - 14 Sept
Courtyard by Marriott Cape Girardeau Downtown
Courtyard by Marriott Cape Girardeau DowntownCape Girardeau
€122
includes taxes & fees
20 Sept - 21 Sept
Hampton Inn Cape Girardeau I 55 East
Hampton Inn Cape Girardeau I 55 EastCape Girardeau
€103
includes taxes & fees
4 Oct - 5 Oct
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
€98
includes taxes & fees
13 Sept - 14 Sept
Tru By Hilton Cape Girardeau
Tru By Hilton Cape GirardeauCape Girardeau
€88
includes taxes & fees
20 Sept - 21 Sept
Candlewood Suites Cape Girardeau by IHG
Candlewood Suites Cape Girardeau by IHGCape Girardeau
€84
includes taxes & fees
4 Oct - 5 Oct
Quality Inn Cape Girardeau North
Quality Inn Cape Girardeau NorthCape Girardeau
€60
includes taxes & fees
4 Oct - 5 Oct
Town House Inn Cape Giradreau
Town House Inn Cape GiradreauCape Girardeau
€75
includes taxes & fees
5 Sept - 6 Sept
Drury Inn & Suites Jackson MO
Drury Inn & Suites Jackson MOJackson
€75
includes taxes & fees
21 Sept - 22 Sept
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
€86
includes taxes & fees
7 Sept - 8 Sept
Comfort Suites Jackson-Cape Girardeau
Comfort Suites Jackson-Cape GirardeauJackson
Comfort Suites Jackson-Cape Girardeau
EC Reed's Mercantile and Hotel
EC Reed's Mercantile and HotelMarble Hill
€79
includes taxes & fees
6 Sept - 7 Sept
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€102
for 1 room
includes taxes & fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
€131
for 1 room
includes taxes & fees
€130
for 1 room
includes taxes & fees
€117
for 1 room
includes taxes & fees
€100
for 1 room
includes taxes & fees
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
€140
for 1 room
includes taxes & fees
€81
for 1 room
includes taxes & fees
€75
for 1 room
includes taxes & fees
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
€234
for 1 room
includes taxes & fees
€243
for 1 room
includes taxes & fees
Check out pet-friendly hotels in Cape Girardeau
€70
includes taxes & fees
27 Sept - 28 Sept
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
€97
includes taxes & fees
13 Sept - 14 Sept
€87
includes taxes & fees
13 Sept - 14 Sept
€88
includes taxes & fees
22 Sept - 23 Sept
€103
includes taxes & fees
4 Oct - 5 Oct
€84
includes taxes & fees
4 Oct - 5 Oct
€75
includes taxes & fees
5 Sept - 6 Sept
You can also stay at hotels with a pool in Cape Girardeau
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
€97
includes taxes & fees
13 Sept - 14 Sept
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHGCape Girardeau
€99
includes taxes & fees
24 Sept - 25 Sept
€87
includes taxes & fees
13 Sept - 14 Sept
€88
includes taxes & fees
22 Sept - 23 Sept
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
€98
includes taxes & fees
13 Sept - 14 Sept
€103
includes taxes & fees
4 Oct - 5 Oct
€60
includes taxes & fees
4 Oct - 5 Oct
€84
includes taxes & fees
4 Oct - 5 Oct
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all propertiesGo beyond your typical stay in Cape Girardeau
Pet friendly
Family friendly
Our prices for hotels in Cape Girardeau are cheapest in December
Our prices for hotels in Cape Girardeau are cheapest in December
Price trends for hotels in Cape Girardeau
Pricing is based on two traveller single night rates
Top landmarks in Cape Girardeau
Southeast Missouri State University
8.8/10 (248 reviews)
If you'd like to get a taste of Cape Girardeau student life, check out Southeast Missouri State University, located 0.9 mi (1.4 km) from central Cape Girardeau.
Riverfront Bridge Park
8.8/10 (129 reviews)
Riverfront Bridge Park is worth a visit, located 0.7 mi (1.1 km) from central Cape Girardeau.
Century Casino & Hotel Cape Girardeau
8.4/10 (176 reviews)
Century Casino & Hotel Cape Girardeau is 0.5 mi (0.8 km) from central Cape Girardeau, why not stop by during your stay?
Hunter Valley Winery
7.4/10 (48 reviews)
Travellers might want a tour of Hunter Valley Winery, just one of the places to visit, located 9.3 mi (14.9 km) from central Cape Girardeau.
Riverfront Park
8.0/10 (2 reviews)
Riverfront Park is worth a visit when in central Cape Girardeau.
Show Me Center
8.6/10 (40 reviews)
You can catch an event at Show Me Center, located 1.1 mi (1.8 km) from central Cape Girardeau.
Cape Rock Park
8.6/10 (36 reviews)
Cape Rock Park is worth a visit, located 1.9 mi (3.1 km) from central Cape Girardeau.
Cape Splash Family Aquatic Center
8.6/10 (21 reviews)
Why not give yourself a treat with a trip to Cape Splash Family Aquatic Center, one of the family attractions located 3.1 mi (5.1 km) from central Cape Girardeau? If you have fun at Cape Splash Family Aquatic Center, you'll love Cape Girardeau Conservation Nature Center, located nearby.
Learn more about Cape Girardeau
Hugging the Mississippi River, this college town reveals its history through vibrant floodwall murals that transform concrete into an outdoor gallery. Southeast Missouri State University brings youthful energy to streets lined with locally-owned shops and cafes. The River Campus hosts performances in a former seminary with river views. Explore the Cape Girardeau Conservation Nature Centre or paddle the Mississippi. Trail of Tears State Park offers hiking paths with panoramic vistas that explain why settlers chose this dramatic spot. The Cape Riverfront Market buzzes with farmers and artisans, while the historic city centre invites exploration with red-brick buildings housing quirky boutiques and restaurants serving hearty Midwestern fare with surprising sophistication.
See all hotels in Cape Girardeau
Check out reviews of Cape Girardeau hotels guests love
Drury Plaza Hotel Cape Girardeau Conference Center
10/10 Excellent
"Everything was awesome! Breakfast was delicious, rooms spacious and clean."
Pear Tree Inn Cape Girardeau West
10/10 Excellent
"Clean room friendly staff"
Tru By Hilton Cape Girardeau
10/10 Excellent
"Clean, quiet - and EV chargers both on and adjacent (Tesla Supercharger) to hotel property."
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
10/10 Excellent
"This location is a must stay any time I am traveling in the area. The staff are helpful. There are lots of dinning options near by. I can always count on a peaceful night sleep at this location."
Candlewood Suites Cape Girardeau by IHG
10/10 Excellent
"Beautiful nice clean place. Beds are so comfortable too! Just wished they offered breakfast"
Fairfield Inn & Suites by Marriott Cape Girardeau
10/10 Excellent
"The room was beautiful and had everything needed!! So clean!"
Town House Inn Cape Giradreau
10/10 Excellent
"If your looking for a budget friendly hotel to stay that is clean or if you need a place to call home for a month till you find a place, I highly recommend this hotel."
Frequently asked questions
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